Stephen J.LurieMD, PhD, Senior EditorIndividualAuthorJody W.ZylkeMD, Contributing EditorIndividualAuthor
In Reply: We agree with Dr Meier and colleagues
that differences in study design led to different estimates of fracture risk,
but we took great care to assess the reasons for this. Exclusion of controls
with a randomly selected index date did not change the results appreciably;
furthermore, risk changed little after excluding patients with a history of
osteoporosis, osteomalacia, cancer, alcoholism, or bisphosphonate use (odds
ratio [OR], 1.06; 95% confidence interval, 0.92-1.23).
van Staa T, Wegman S, de Vries F, Leufkens B, Cooper C. Statins and Fracture Risk—Reply. JAMA. 2001;286(6):669–670. doi:10.1001/jama.286.6.669
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