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August 8, 2001

Statins and Fracture Risk—Reply

Author Affiliations

Stephen J.LurieMD, PhD, Senior EditorIndividualAuthorJody W.ZylkeMD, Contributing EditorIndividualAuthor

JAMA. 2001;286(6):669-670. doi:10.1001/jama.286.6.669

In Reply: We agree with Dr Meier and colleagues that differences in study design led to different estimates of fracture risk, but we took great care to assess the reasons for this. Exclusion of controls with a randomly selected index date did not change the results appreciably; furthermore, risk changed little after excluding patients with a history of osteoporosis, osteomalacia, cancer, alcoholism, or bisphosphonate use (odds ratio [OR], 1.06; 95% confidence interval, 0.92-1.23).