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August 15, 2001

Sex Hormones, Amyloid Protein, and Alzheimer Disease—Reply

Author Affiliations

Stephen J.LurieMD, PhD, Senior EditorIndividualAuthorJody W.ZylkeMD, Contributing EditorIndividualAuthor

JAMA. 2001;286(7):790-791. doi:10.1001/jama.286.7.790

In Reply: We agree with Dr Bowen that it is possible that intermediate hormones of the hypothalamic-pituitary-gonadal axis might be perturbed in AD. However, we strongly caution against the use of leuprolide for any disorder of cognition since 3 independent reports have established that memory loss and depression are among its adverse effects.1-3