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September 26, 2001

Relationship Between Apolipoprotein E ∊4 and Sleep-Disordered Breathing at Different Ages—Reply

Author Affiliations

Stephen J.LurieMD, PhD, Senior EditorIndividualAuthorJody W.ZylkeMD, Contributing EditorIndividualAuthor

JAMA. 2001;286(12):1447-1448. doi:10.1001/jama.286.12.1447

In Reply: Mr Foley and colleagues offer an insightful follow-up to our report indicating increased risk for SDB with ApoE4. In their study, ApoE4 did not increase risk for SDB in Japanese-American men aged 79 to 97 years. Although additional studies are needed to confirm our finding, the discrepancy is most likely due to age, population, and design differences. As pointed out by Foley et al, men aged 79 to 97 years comprised their sample; our study is based on a community sample of men and women aged 30 to 60 years.