Copyright 2001 American Medical Association. All Rights Reserved.
Applicable FARS/DFARS Restrictions Apply to Government Use.2001
In Reply: We agree that both case-control and
cross-sectional studies have limitations in defining a causal association
between an exposure and a disease because of the inability to accurately define
the temporal relationship between the variables. In our study, we assumed
that the poststroke HDL-C measurement was a proxy for prestroke HDL-C. We
cited references that support the relative stability of HDL-C in acute situations.1-3 There is no
literature that suggests that stroke will lead to a decrease in HDL-C acutely.
Whether other confounding prior conditions led to a decrease in HDL-C and
also increased the risk of stroke is unknown. We adjusted for multiple other
risk factors and still found an independent association between HDL-C and
Sacco RL, Boden-Albala B. High-Density Lipoprotein Cholesterol and Risk of Stroke—Reply. JAMA. 2001;286(13):1573–1574. doi:10.1001/jama.286.13.1573
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