Copyright 2001 American Medical Association. All Rights Reserved.
Applicable FARS/DFARS Restrictions Apply to Government Use.2001
In Reply: Dr Goldman and colleagues focus on
a small number of our underpowered results and hypotheses based upon others'
data. Instead, we chose to focus on a set of a priori hypotheses consistent
with our hypothesized mechanism and for which we expected adequate statistical
power. The surprising borderline significant association with the use of asthma
or allergy drugs was not an a priori hypothesis and so was not reported in
our abstract; although interesting, this data-derived hypothesis remains to
be tested. We did not study autoimmune disease, including the autoimmune thyroid
disease hypothesized in the study by Fort et al,1
since this diagnosis is too uncommon. Furthermore, we found no difference
in the incidence of thyroid disease (Table
1). Ours also was a young cohort that may not yet have developed,
or been diagnosed with, endometriosis or fibroids. However, the absence of
a strong association in our data with either of these outcomes does not support
such hypotheses (Table 1). Goldman
et al are concerned that we did not present reasons for male infertility,
but once again, the numbers were too small to be reliable (Table 1).
Strom BL, Schinnar R, Barnhart KT, Sammel MD, Macones GA, Stallings VA. Exposure to Soy-Based Formula in Infancy—Reply. JAMA. 2001;286(19):2402–2403. doi:10.1001/jama.286.19.2398
Customize your JAMA Network experience by selecting one or more topics from the list below.
Create a personal account or sign in to: