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November 21, 2001

Exposure to Soy-Based Formula in Infancy—Reply

Author Affiliations

Copyright 2001 American Medical Association. All Rights Reserved. Applicable FARS/DFARS Restrictions Apply to Government Use.2001

JAMA. 2001;286(19):2402-2403. doi:10.1001/jama.286.19.2398

In Reply: Dr Goldman and colleagues focus on a small number of our underpowered results and hypotheses based upon others' data. Instead, we chose to focus on a set of a priori hypotheses consistent with our hypothesized mechanism and for which we expected adequate statistical power. The surprising borderline significant association with the use of asthma or allergy drugs was not an a priori hypothesis and so was not reported in our abstract; although interesting, this data-derived hypothesis remains to be tested. We did not study autoimmune disease, including the autoimmune thyroid disease hypothesized in the study by Fort et al,1 since this diagnosis is too uncommon. Furthermore, we found no difference in the incidence of thyroid disease (Table 1). Ours also was a young cohort that may not yet have developed, or been diagnosed with, endometriosis or fibroids. However, the absence of a strong association in our data with either of these outcomes does not support such hypotheses (Table 1). Goldman et al are concerned that we did not present reasons for male infertility, but once again, the numbers were too small to be reliable (Table 1).