Atypical Antipsychotic Drugs and Hyperglycemia in Adolescents

To the Editor: Hyperglycemia has been associated with the atypical antipsychotic agents clozapine and olanzapine,¹ and a recent case report described diabetic ketoacidosis associated with olanzapine in a pediatric patient.² To gain further insight into the association between hyperglycemia and these 2 drugs in the pediatric population, we queried the US Food and Drug Administration (FDA) MedWatch drug surveillance system to identify cases occurring in patients younger than 19 years.