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November 28, 2001

Atypical Antipsychotic Drugs and Hyperglycemia in Adolescents

Author Affiliations

Copyright 2001 American Medical Association. All Rights Reserved. Applicable FARS/DFARS Restrictions Apply to Government Use.2001

JAMA. 2001;286(20):2547-2548. doi:10.1001/jama.286.20.2542

To the Editor: Hyperglycemia has been associated with the atypical antipsychotic agents clozapine and olanzapine,1 and a recent case report described diabetic ketoacidosis associated with olanzapine in a pediatric patient.2 To gain further insight into the association between hyperglycemia and these 2 drugs in the pediatric population, we queried the US Food and Drug Administration (FDA) MedWatch drug surveillance system to identify cases occurring in patients younger than 19 years.