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December 5, 2001

Using Meta-analysis to Answer Clinical Questions—Reply

Author Affiliations

Stephen J.LurieMD, PhD, Senior EditorIndividualAuthorJody W.ZylkeMD, Contributing EditorIndividualAuthor

JAMA. 2001;286(21):2669-2670. doi:10.1001/jama.286.21.2665

In Reply: We agree with Dr Laheij that exploration of heterogeneity sources may provide valuable information, especially for controversial medical topics for which therapeutic or preventive effects of different magnitude are obtained by different study designs.1 We also agree that empirical meta-analytic evaluations can be applied in other types of studies as well.

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