Stephen J.LurieMD, PhD, Senior EditorIndividualAuthorJody W.ZylkeMD, Contributing EditorIndividualAuthor
To the Editor: Dr Lemanske and colleagues1 concluded that the addition of salmeterol to ICs
may improve overall asthma control. Unfortunately, its second conclusion,
that salmeterol may safely facilitate halving the dose of IC, is not entirely
supported by the data.
For the primary outcome variable, the overall number of treatment failures
during the reduction and elimination phases, results were similar comparing
the placebo-minus (47%) and salmeterol-minus (43%) groups. In other words,
the addition of salmeterol made no clinically relevant impact over the 16-week
Fowler SJ, Lipworth BJ. Salmeterol and Inhaled Corticosteroids in Patients With Persistent Asthma. JAMA. 2001;286(24):3075–3078. doi:10.1001/jama.286.24.3075
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