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December 26, 2001

Salmeterol and Inhaled Corticosteroids in Patients With Persistent Asthma—Reply

Author Affiliations

Stephen J.LurieMD, PhD, Senior EditorIndividualAuthorJody W.ZylkeMD, Contributing EditorIndividualAuthor

JAMA. 2001;286(24):3075-3078. doi:10.1001/jama.286.24.3075

In Reply: Our study was designed to compare directly the 2 salmeterol-treated groups. The group that received placebo (salmeterol) was limited in enrollment to safely evaluate whether the rate of failure following reduction and elimination of ICs would be similar to that reported by others, and to document that the patients enrolled required IC therapy to maintain adequate asthma control. As Drs Fowler and Lipworth acknowledge, both of these outcomes were observed.