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February 13, 2002

Drug-Related Hyperglycemia

Author Affiliations

Stephen J.LurieMD, PhD, Senior EditorIndividualAuthor

JAMA. 2002;287(6):714-715. doi:10.1001/jama.287.6.711

To the Editor: In their article on drug-induced hyperglycemia, Drs Luna and Feinglos1 did not discuss growth hormone (GH), which is known to induce hyperglycemia.2,3 The approved indications for GH have expanded substantially in the United States in the last several years. For growth-enhancing purposes, GH indications now include short stature associated with small gestational age and Prader Willi and Turner syndromes.4 In addition, GH has also been approved for the treatment of cachexia associated with acquired immunodeficiency syndrome (AIDS).4 For all of these conditions, and particularly AIDS-associated cachexia, dosages are in excess of those previously indicated for replacement therapy in children with GH deficiency. Higher dosages of GH are also approved for the treatment of GH deficiency in adolescents, and GH has also been approved as replacement therapy for adults with GH deficiency.4 The recommended doses for adults, however, are substantially smaller than for children.