Stephen J.LurieMD, PhD, Senior EditorIndividualAuthor
To the Editor: In their article on drug-induced
hyperglycemia, Drs Luna and Feinglos1 did
not discuss growth hormone (GH), which is known to induce hyperglycemia.2,3 The approved indications for
GH have expanded substantially in the United States in the last several years.
For growth-enhancing purposes, GH indications now include short stature associated
with small gestational age and Prader Willi and Turner syndromes.4 In addition, GH has also been approved for the
treatment of cachexia associated with acquired immunodeficiency syndrome (AIDS).4 For all of these conditions, and particularly AIDS-associated
cachexia, dosages are in excess of those previously indicated for replacement
therapy in children with GH deficiency. Higher dosages of GH are also approved
for the treatment of GH deficiency in adolescents, and GH has also been approved
as replacement therapy for adults with GH deficiency.4
The recommended doses for adults, however, are substantially smaller than
Molazowski S. Drug-Related Hyperglycemia. JAMA. 2002;287(6):714–715. doi:10.1001/jama.287.6.711
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