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February 13, 2002

Identifying Genetic Factors in Parkinson Disease—Reply

Author Affiliations

Stephen J.LurieMD, PhD, Senior EditorIndividualAuthor

JAMA. 2002;287(6):715-716. doi:10.1001/jama.287.6.711

In Reply: We agree with Dr Farrer and colleagues that our data demonstrate a link between the tau gene and PD. However, their suggestion that the genomic screen by DeStefano et al1 has comparable power to our study is incorrect. Our genomic screen2 used a much more powerful data set with 3 times as many affected individuals (103 vs 378) and 4 times as many genotyped individuals (219 vs 870). This increased power led to the identification of additional loci, including the parkin gene, that DeStefano et al could not detect with their smaller sample.