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April 3, 2002

Drug Therapy for Patients With Type 2 Diabetes

Author Affiliations

Stephen J.LurieMD, PhD, Senior EditorIndividualAuthor

JAMA. 2002;287(13):1645-1646. doi:10.1001/jama.287.13.1645

To the Editor: I have several concerns about Dr Inzucchi's review1 of oral antihyperglycemic therapy. First, he described the effects of various agents only in terms of comparison with placebo rather than with baseline values. This way of presenting the data can be misleading. In diabetes clinical trials, glycemic control frequently deteriorates in the placebo group, which amplifies the efficacy of active therapy.