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April 3, 2002

Poliomyelitis and Parkinson Disease

Author Affiliations

Stephen J.LurieMD, PhD, Senior EditorIndividualAuthor

JAMA. 2002;287(13):1650-1651. doi:10.1001/jama.287.13.1645

To the Editor: Parkinson disease (PD), which is due to loss of dopaminergic neurons in the zona compacta of the substantia nigra,1 may involve both genetic and environmental risk factors.2 Poliovirus is believed to cause neuronal damage in the substantia nigra,3 and thus a history of poliovirus infection may be associated with an increased risk of PD.4