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April 10, 2002

Rofecoxib vs Celecoxib vs Acetaminophen for Treatment of Osteoarthritis

Author Affiliations

Stephen J.LurieMD, PhD, Senior EditorIndividualAuthor

JAMA. 2002;287(14):1799-1800. doi:10.1001/jama.287.14.1799

To the Editor: Dr Geba and colleagues1 concluded that rofecoxib (25 mg/d) is more efficacious than acetaminophen (400 mg/d) and celecoxib (200 mg/d). However, 400 mg/d of celecoxib would have been a more appropriate comparison dose. In any event, the differences in outcomes did not appear to be clinically significant.

Merck (which makes rofecoxib) sponsored this study and all authors were affiliated with either Merck or its speaker's bureau. I fear that the results of this study may be used to support advertising directly to consumers and increase the time I will needlessly spend educating my patients.