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April 17, 2002

Is One Selective Serotonin Reuptake Inhibitor Better Than Another?

Author Affiliations

Stephen J.LurieMD, PhD, Senior EditorIndividualAuthor

JAMA. 2002;287(15):1935-1938. doi:10.1001/jama.287.15.1935

To the Editor: We question the main conclusion of Dr Kroenke and colleagues1 that paroxetine, fluoxetine, and sertraline had similar efficacy for the treatment of depressive symptoms and improvement in health-related quality of life. Although there were no statistically significant differences when the measures were analyzed individually, we noticed a pattern in the outcomes that did not appear to be random.