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April 17, 2002

Lactobacillus Strains and Vaginal Ecology

Author Affiliations

Stephen J.LurieMD, PhD, Senior EditorIndividualAuthor

JAMA. 2002;287(15):1940-1941. doi:10.1001/jama.287.15.1935

To the Editor: Depletion of vaginal lactobacilli has been associated with increased risk of urogenital infections including bacterial vaginosis (BV) and acquisition of human immunodeficiency virus (HIV).1 We conducted a randomized controlled trial to compare combination therapy with probiotic Lactobacillus rhamnosus GR-1 and L fermentum RC-14 vs commercially available Lactobacillus rhamnosus GG in colonizing the vagina following menstruation. The GG strain, however, may not be an optimal choice to prevent urogenital infections, as it has been shown to be ineffective in preventing urinary tract infections.2 Furthermore, unlike RC-14, GG does not express any anti-infective proteins against urogenital pathogens.3 We therefore also sought to determine whether GR-1 and RC-14 have antiyeast and antiviral properties.