In Reply: In response to Drs Fiorelli and von
Kummer, our definition of EIC is consistent with current and prior work, and
the prevalence of EICs in the NINDS rt-PA Stroke Trial1
is comparable to that in ECASS I done during a similar time period (1991-1994).2
Patel SC, Levine SR, Tilley BC, . Early Ischemic Changes on Computed Tomography in Patients With Acute Stroke—Reply. JAMA. 2002;287(18):2361–2362. doi:10.1001/jama.287.18.2359
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