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July 17, 2002

Effects of Leptin on Platelet Function in Obese Patients

Author Affiliations

Copyright 2002 American Medical Association. All Rights Reserved. Applicable FARS/DFARS Restrictions Apply to Government Use.2002

JAMA. 2002;288(3):313-314. doi:10.1001/jama.288.3.311

To the Editor: Dr Bodary and colleagues1 found that leptin contributed to arterial thrombosis following photochemical vascular injury in mice. Recently, Konstantinides et al2 reported similar results with the ferric chloride model of carotid artery injury. A common factor of these findings may be the ability of leptin to enhance platelet aggregation through the stimulation of the long form of its receptor on the platelet membrane.2-4

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