Stephen J.LurieMD, PhD, Senior EditorIndividualAuthor
To the Editor: Dr Walsh and colleagues1 found a trend toward increasing placebo effect
with younger birth cohorts in trials of antidepressants. The best fit lines
of the medication groups vs placebo group in 75 trials are parallel, suggesting
that the increasing effect in younger birth cohorts is mostly due to increasing
placebo effects. With a mean 50% proportion of patients responding to actual
therapeutic drugs, it would appear that the placebo and drug effects (although
additive) are more or less equal.
Sapir M. The Increasing Power of Placebos in Trials of Antidepressants. JAMA. 2002;288(4):449–450. doi:10.1001/jama.288.4.446
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