Copyright 2002 American Medical Association. All Rights Reserved.
Applicable FARS/DFARS Restrictions Apply to Government Use.2002
To the Editor: The cost of some medication
regimens can be decreased by as much as 50% if patients split high-dose tablets
to achieve an intended lower dose.1 Some
studies have concluded that tablet splitting does not affect compliance.1 On the other hand, actual dosages of hand-split
tablets may deviate by more than 20%, and some patients may be willing to
pay more to avoid splitting.1,2
Another study, however, found that splitting lisinopril did not change control
of stable hypertension, and most patients were willing to split tablets.3 Nonetheless, a recent literature review concluded
available literature was too limited to adequately address the safety of this
Peek BT, Al-Achi A, Coombs SJ. Accuracy of Tablet Splitting by Elderly Patients. JAMA. 2002;288(4):451–452. doi:10.1001/jama.288.4.446
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