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September 25, 2002

Effect of Sleep Deprivation on Response to Immunizaton

Author Affiliations

Stephen J.LurieMD, PhD, Senior EditorIndividualAuthor

JAMA. 2002;288(12):1471-1472. doi:10.1001/jama.288.12.1469

To the Editor: Popular wisdom holds that not getting enough sleep increases the propensity of catching a cold or other ailments. In America, sleep duration has steadily declined from nearly 9 hours in 1960 to less than 7 hours currently.1,2 Although adverse effects of sleep deprivation on immune parameters have been documented,3 the clinical implications of these findings are unclear. We examined the effect of sleep deprivation on immune response to influenza vaccination.

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