Stephen J.LurieMD, PhD, Senior EditorIndividualAuthor
In Reply: Dr Terao cautions that factors other
than lipid solubility and generation may influence the risks of adverse effects
of β-blockers, and that there may be an inconsistent relationship between β-blockers
and depressive symptoms. We acknowledge that there is evidence of a beneficial
effect of pindolol in combination with paroxetine on depression.1 Of
the trials in our meta-analysis, only the STOP-Hypertension (Swedish Trial
in Old Patients with Hypertension) trial2 tested
pindolol. Although there was no significant difference in the risk of depression
between the treatment groups, the sample size was too small to confirm (or
disprove) any protective effect.
Ko DT, Hebert PR, Curtis JP, Krumholz HM, Sedrakyan A, Coffey CS. β-Blocker Therapy and Depression—Reply. JAMA. 2002;288(15):1845–1846. doi:10.1001/jama.288.15.1845
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