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November 6, 2002

Spontaneous and Sporadic Trypsinogen Mutations in Idiopathic Pancreatitis

Author Affiliations

Copyright 2002 American Medical Association. All Rights Reserved. Applicable FARS/DFARS Restrictions Apply to Government Use.2002

JAMA. 2002;288(17):2122. doi:10.1001/jama.288.17.2118

To the Editor: Hereditary pancreatitis is an uncommon variety of pancreatitis. It generally follows an autosomal dominant inheritance and is associated with germline mutations in the cationic trypsinogen (PRSS1) gene.1 Thus, genetic testing is often recommended when 2 or more family members are diagnosed with idiopathic pancreatitis. However, the prevalence of trypsinogen mutations among patients with idiopathic pancreatitis and without a family history remains unknown.

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