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Lab Reports
August 3, 2011

Amyloid and Alzheimer Disease

JAMA. 2011;306(5):480. doi:10.1001/jama.2011.1086

A protein encoded by a variant of the APOE gene that is implicated in many cases of late-onset sporadic Alzheimer disease slows clearance of amyloid-β, contributing to amyloid-β build-up in the brain (Castellano JM et al. Sci Transl Med. 2011;3[89]:89ra57).

In cognitively normal individuals who are younger than age 70 years, those with APOE ε4 protein had significantly more amyloid-β protein in the brain than individuals with either APOE ε2 and APOE ε3, the proteins encoded by other variants of the APOE gene.