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September 14, 2011

Urinary Sodium Excretion and Cardiovascular Disease Mortality

Author Affiliations

Author Affiliations: Institute of Social and Preventive Medicine, Lausanne, Switzerland (murielle.bochud@chuv.ch).

JAMA. 2011;306(10):1083-1087. doi:10.1001/jama.2011.1293

To the Editor: The inverse association between urinary sodium excretion and CVD mortality found in a recent prospective cohort study1 challenges strategies to reduce salt intake in populations that are being implemented in an increasing number of countries.2 We would like to point out a few issues related to internal validity (potential exposure misclassification, confounding, and survival bias) and external validity (age of the participants in the study).