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September 21, 2011

Time to Initiation of Adjuvant Chemotherapy and Survival in Colorectal Cancer

Author Affiliations

Author Affiliation: Jikei University of School of Medicine, Tokyo, Japan (tetsu@jg8.so-net.ne.jp).

JAMA. 2011;306(11):1199-1200. doi:10.1001/jama.2011.1320

To the Editor: In the report by Dr Biagi and colleagues,1 a 4-week delay in time to initiation of adjuvant chemotherapy after curative resection of stage II and stage III colorectal cancer was associated with a 14% reduction in both overall and disease-free survival. The authors mentioned that the effect of adjuvant chemotherapy on survival may be the result of eradication of micrometastatic deposits of cancer cells and hypothesized that chemotherapy would be most effective if initiated when tumor burden is low.