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January 25, 2012

Children, Asthma, and Proton Pump Inhibitors: Costs and Perils of Therapeutic Creep

Author Affiliations

Author Affiliations: Arizona Respiratory Center, BIO5 Institute and Clinical and Translational Science Institute, University of Arizona, Tucson.

JAMA. 2012;307(4):406-407. doi:10.1001/jama.2012.33

Children with asthma report symptoms of gastroesophageal reflux disease (GERD) more often than children without asthma.1 Nevertheless, a systematic review of the child health literature, which included studies using pH probes and other objective assessment methods, concluded that the true nature of the association between GERD and asthma, their temporal relation, and the causal direction, remain unknown.2 Moreover, the potential for antiacid therapy to improve asthma symptoms in children with poorly controlled disease remains largely anecdotal. A small, randomized placebo-controlled trial showed no improvement in asthma status among children treated with omeprazole for 12 weeks.3

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