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February 15, 2012

Vitamin D in Chronic Kidney Disease: More Questions Than Answers

Author Affiliations

Author Affiliations: Division of Applied Cachexia Research, Department of Cardiology, Charité Campus Virchow-Klinikum (Drs Anker and von Haehling), and Center for Cardiovascular Research, Charité Medical School, Campus Mitte (Dr von Haehling), Berlin, Germany; and Centre for Clinical and Basic Research, IRCCS San Raffaele, Rome, Italy (Dr Anker).

JAMA. 2012;307(7):722-723. doi:10.1001/jama.2012.159

Dietary vitamin D supplementation is advocated throughout the world, and in recent years it has received substantial public interest.1 Vitamin D metabolism is complex. The active metabolite 1,25-hydroxyvitamin D is involved in calcium and phosphorus homeostasis and the vitamin D receptor is expressed in many tissues, such as skeletal muscle, brain, prostate, breast, colon, and immune cells.2 Vitamin D status is usually assessed by measurement of the inactive metabolite 25-hydroxyvitamin D in serum, but no consensus exists on optimal serum levels.2