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Capitol Health Call
March 14, 2012

Antibiotic Breakpoints

JAMA. 2012;307(10):1015. doi:10.1001/jama.2012.255

The Food and Drug Administration (FDA) has not taken significant steps to ensure that antibiotic labels contain up-to-date breakpoints, according to a Government Accountability Office (GAO) report.

Breakpoints are the concentrations at which bacteria are susceptible to successful treatment with an antibiotic. At a time when antibiotic resistance is increasing, long-time established breakpoints may underestimate antibiotic dosage levels, leading to undertreatment of bacterial infections.

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