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Health Agencies Update
March 28, 2012

HIV, Hepatitis Drug Interactions

JAMA. 2012;307(12):1243. doi:10.1001/jama.2012.332

Certain combinations of medications used to treat HIV and hepatitis C infection may lead to lower blood levels of these drugs, potentially reducing their efficacy, according to a US Food and Drug Administration (FDA) alert.

Citing evidence from a pharmacokinetic study, the FDA warned that patients taking the hepatitis C–targeted protease inhibitor boceprevir along with any of the ritonavir-boosted HIV-targeting protease inhibitors atazanavir, darunavir, or lopinavir may have lower blood levels of 1 or both drugs. The label of boceprevir will be updated to indicate this potential interaction, and the drug's manufacturer has sent letters to warn physicians.

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