In a female patient suffering from well-marked and typical acromegaly of four years' duration, a constant excretion of creatin has been observed. The excretion varied from a minimum of 52 mg. to a maximum of 500 mg., the average excretion being between 100 and 150 mg. a day. The great variation in the amount of daily excretion is undoubtedly largely due to the impossibility of obtaining satisfactory twenty-four-hour samples, the patient being up and about during the whole period of observation.
The daily output of total nitrogen, creatinin and creatin is given in Table 1. The creatinin and creatin were both determined by the Folin method; total nitrogen by the Kjeldahl method.
From these figures it can be seen that there was a constant excretion of creatin during the period in which the patient was under observation; that this excretion, while not constant, tended to constitute about 20 per cent,
ELLIS AWM. THE URINE IN A CASE OF ACROMEGALY. JAMA. 1911;LVI(25):1870–1871. doi:10.1001/jama.1911.02560250004002
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