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Article
November 13, 1915

THE ACETONE BODIES IN DIABETES MELLITUS: INFLUENCE OF LOW AND HIGH PROTEIN INTAKE ON THE EXCRETION OF ACETONE, DIACETIC ACID AND BETA-OXYBUTYRIC ACID

Author Affiliations

PITTSBURGH

JAMA. 1915;LXV(20):1715-1717. doi:10.1001/jama.1915.02580200029008
Abstract

INTRODUCTION AND REVIEW OF LITERATURE  I have frequently noted that the administration of increased amounts of protein to diabetics often increases the amounts of acetone, diacetic acid and beta-oxybutyric acid excreted in the urine. Magnus Levy1 has had a similar experience, and asserts that the increased excretion of the acetone bodies does not mean that they have been formed from the protein but on account of the high protein content of the diet, which makes an extra tax on the oxidizing powers of the body and diverts these from the combustion of the acetone bodies.It is now firmly settled that the acetone bodies are mostly derived from the fats and especially from the fats composed of the lower fatty-acids.2 Knoop,3 Ringer4 and others have shown that in the catabolism of fatty acids the carbon chains are broken down by the oxidation of the third carbon

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