This investigation of the diazo and urochromogen reactions in pulmonary tuberculosis was suggested mainly by an article in which Schäffle1 pointed out, as significant features of his examination, the "difference in mortality percentages between the positive and negative cases and particularly the high death rate among those with a negative diazo and positive urochromogen test."
Schäffle also referred to the original work of Weiss, who, after seven years of investigation, confirmed the
observations of Koch that death invariably followed the persistent presence of the diazo reaction in the urine of the tuberculous. Weiss also refers to the frequent disappearance of the diazo reaction shortly before death in tuberculous cases.
The investigation of these reactions was further instigated by the statement of Webster,2 that "the presence of urochromogen is a contraindication to the tuberculin treatment in tuberculous conditions."
The investigation, therefore, had a twofold purpose: (1) to discover, if
SINCLAIR AN. THE DIAZO AND UROCHROMOGEN REACTIONS IN PULMONARY TUBERCULOSIS. JAMA. 1916;LXVI(4):247–248. doi:10.1001/jama.1916.02580300015004
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