During an intensive campaign for the detection and treatment of hookworm disease in Trinidad, British West Indies, under the direction of the surgeongeneral of the colony, experiments were conducted for determining the efficacy of thymol when administered in capsule form with varying proportions of lactose and with sodium bicarbonate. The routine method employed in the treatment of the disease was to give each patient two treatments (the drug being administered in every instance by a trained assistant), one week apart, and then make a microscopic examination, using the centrifuge, six days after the second treatment, of a specimen of the bowel excretion to determine whether or not a cure had been effected. In making the experiments the drug was administered in each case by the same assistants, in the same manner and the same doses, and to patients living under the same conditions.
For the purposes of the first experiment,
WASHBURN BE. USE OF THYMOL IN TREATMENT OF HOOKWORM DISEASE. JAMA. 1917;LXVIII(16):1162–1163. doi:10.1001/jama.1917.04270040150003
Coronavirus Resource Center
Customize your JAMA Network experience by selecting one or more topics from the list below.
Create a personal account or sign in to: