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Article
October 15, 1898

A CONTRIBUTION TO THE PHARMACOLOGY OF CANNABIS INDICA.

JAMA. 1898;XXXI(16):882-891. doi:10.1001/jama.1898.92450160001002
Abstract

Notwithstanding the large amount of labor which has been expended on Indian hemp, we know comparatively little of its pharmacology. The active principle, it is true, has been isolated, in a more or less impure form, by O'Shaughnessy, Robertson, the brothers Smith, and more recent investigators, but the more important question of the changes this undergoes has not, as far as I am aware, until recently,

been attempted. To me this is the most interesting part of the inquiry. Apart from the great financial loss entailed by the growing inertness with age of the drug, the variability in the strength, its preparation has led to numerous misfortunes in medical practice, and a distrust in its use as a therapeutic agent. The isolation of the active principle of the drug would not matter if we could only insure our preparations being of constant strength. But, without knowing the cause of the

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