Members of the Methodology Committee of PCORI: Ethan Basch, MD, MSc (Memorial Sloan-Kettering Cancer Center, New York, New York); Naomi Aronson, PhD (Blue Cross Blue Shield Association, Chicago, Illinois); Alfred Berg, MD, MPH (University of Washington, Seattle); David Flum, MD, MPH (University of Washington, Seattle); Sherine Gabriel, MD, MSc (chair, Mayo Clinic, Rochester, Minnesota); Steven N. Goodman, MD, MHS, PhD (Stanford University, Stanford, California); Mark Helfand, MD, MS, MPH (Portland VA Medical Center, Portland, Oregon); John P. A. Ioannidis, MD, DSc (Stanford University, Stanford, California); Michael Lauer, MD (National Heart, Lung, and Blood Institute, Bethesda, Maryland); David Meltzer, MD, PhD (University of Chicago, Chicago, Illinois); Brian Mittman, PhD (Department of Veterans Affairs, Sepulveda, California); Robin Newhouse, PhD, RN (University of Maryland, Baltimore); Sharon-Lise Normand, MSc, PhD (vice chair, Harvard Medical School and Harvard School of Public Health, Boston, Massachusetts); Sebastian Schneeweiss, MD, ScD (Harvard Medical School, Boston, Massachusetts); Jean Slutsky, PA, MSPH (Agency for Healthcare Research and Quality, Rockville, Maryland); Mary Tinetti, MD (Yale University, New Haven, Connecticut); and Clyde Yancy, MD, MSc (Northwestern University, Chicago, Illinois).