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January 30, 2008

Topiramate as Treatment for Alcohol Dependence

JAMA. 2008;299(4):405-407. doi:10.1001/jama.299.4.405-a

To the Editor: In their clinical trial of topiramate for treating alcohol dependence, Dr Johnson and colleagues1 concluded that topiramate is a safe and efficacious medication. However, it is important to note that the use of topiramate has been associated with acute angle-closure glaucoma among patients with no previous history of ocular disease and no predisposition to glaucoma.2-5 Unless appropriately recognized and treated, the angle closure may result in loss of sight. For those affected, blindness is no less of a problem than alcohol dependence.