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Lab Reports
January 2, 2008

Aging and Antidepressants

JAMA. 2008;299(1):29. doi:10.1001/jama.2007.31

An antidepressant used to treat humans can increase the lifespan of Caenorhabditis elegans nematodes, according to a study by researchers at the Fred Hutchinson Cancer Research Center in Seattle (Petrascheck M et al. Nature. 2007;450[7169]:553-556).

By screening 88 000 chemicals for lifespan-enhancing effects on C elegans, the investigators identified the tetracyclic antidepressant mianserin (approved in New Zealand but not in the United States) as having these effects. Other antidepressants tested did not increase lifespan.