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January 21, 1998

Nicotine Replacement Therapy and Smoking Reduction as an Interim Goal

Author Affiliations

Copyright 1998 American Medical Association. All Rights Reserved. Applicable FARS/DFARS Restrictions Apply to Government Use.1998

JAMA. 1998;279(3):194-195. doi:10.1001/jama.279.3.193

To the Editor.— Dr Warner and colleagues1 questioned whether users of nontobacco nicotine delivery products also would use conventional tobacco products. They noted that over-the-counter availability of nicotine-containing pharmaceuticals would likely increase the use of these products as partial substitutes for smoking.

Even prior to their over-the-counter availability, nicotine-containing pharmaceuticals have been used in combination with conventional tobacco products in studies of smoking cessation.2-5 The particular type of allowed combination has varied widely. During an investigation of nicotine skin patches, participants could smoke an average of 1 cigarette per day over 4 weeks.2 Similarly, participants in an 8-week trial of transdermal nicotine patches who reported irregular or intermittent smoking were allowed to continue using the medication provided they continued to try to quit smoking.3

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