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May 6, 1998

Serum Lipids After a Low-Fat Diet—Reply

Author Affiliations

Margaret A.WinkerMD, Senior EditorIndividualAuthorPhil B.FontanarosaMD, Senior EditorIndividualAuthor

JAMA. 1998;279(17):1345-1346. doi:10-1001/pubs.JAMA-ISSN-0098-7484-279-17-jbk0506

In Reply.—Our interpretation of the results of the Dietary Alternatives Study are regarded as "misleading" by Dr Ornish, who quotes his Lifestyle Heart Trial.1We disagree with this statement. Our purpose was to compare lipoprotein and metabolic response to 4 different diets of increasing fat restriction with targets ranging from 30%, 26%, 22%, and 18% of energy intake as fat. No other interventions were undertaken. In contrast, Ornish studied the effects of multiple interventions to reduce coronary artery narrowing. Thus, the purposes and interpretation of the 2 studies are different.