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May 13, 1998

Hypoglycemia From Glipizide and Glyburide

Author Affiliations

Margaret A.WinkerMD, Senior EditorIndividualAuthorPhil B.FontanarosaMD, Senior EditorIndividualAuthor

JAMA. 1998;279(18):1441-1443. doi:10-1001/pubs.JAMA-ISSN-0098-7484-279-18-jac80006

To the Editor.—The study by Dr Burge and colleagues1 was designed to compare blood glucose levels following a prolonged fast among older persons exposed to glyburide and glipizide. The study is justifiable because glipizide, manufactured by the study sponsor, may stimulate less insulin secretion in the fasting state and may, therefore, produce less hypoglycemia following a prolonged fast than does glyburide.2 Also, there is a 2-fold increase in the risk of serious hypoglycemia among older adults prescribed glyburide compared with glipizide.3 In this experimental setting, there were no differences in fasting glucose levels between glyburide and glipizide and no hypoglycemia occurred among study participants.