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May 27, 1998


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Copyright 1998 American Medical Association. All Rights Reserved. Applicable FARS/DFARS Restrictions Apply to Government Use.1998

JAMA. 1998;279(20):1613-1614. doi:10-1001/pubs.JAMA-ISSN-0098-7484-279-20-jbk0527

To the Editor.—Toxic epidermal necrolysis (TEN) is a serious, usually drug-induced, dermatosis characterized by extensive erythema, necrosis, bullous detachment of the epidermis, constitutional symptoms, and visceral involvement.1-4 We report a case of TEN apparently caused by atorvastatin, an antihyperlipidemic drug in the 3-hydroxy-3-methylglutaryl coenzyme A (HMG-CoA) reductase inhibitor class. We are unaware of any published reports of TEN associated with atorvastatin or related compounds.5

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