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June 10, 1998

Rescreening of Cervical Papanicolaou Smears Using PAPNET—Reply

Author Affiliations

Margaret A.WinkerMD, Senior EditorIndividualAuthorPhil B.FontanarosaMD, Senior EditorIndividualAuthor

JAMA. 1998;279(22):1785-1788. doi:10-1001/pubs.JAMA-ISSN-0098-7484-279-22-jac80008

In Reply.— Dr Greenberg suggests that the traditional Pap smear should be supplemented with HPV testing when ASCUS, AGUS, or LSIL is encountered. Since our study did not address HPV testing, we cannot address the cost-effectiveness of this strategy, but observe that routine Pap smear testing as infrequently as every 3 years can reduce the incidence of invasive cervical cancer by up to 90%.1