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June 24, 1998

CCR5 Genotype and Mother-to-Child HIV Transmission

Author Affiliations

Margaret A.WinkerMD, Senior EditorIndividualAuthorPhil B.FontanarosaMD, Senior EditorIndividualAuthor

JAMA. 1998;279(24):1953. doi:10-1001/pubs.JAMA-ISSN-0098-7484-279-24-jac80011

To the Editor.— In their article, Dr Misrahi and colleagues1 try to correlate a CCR5 gene polymorphism with resistance to perinatal human immunodeficiency virus (HIV) infection and progression of HIV disease. The finding that Hardy-Weinberg equilibrium was obeyed for the cohort as a whole, as well as the discovery that the CCR5Δ32 heterozygotes were distributed statistically evenly between the uninfected and infected children, led them to conclude that such a genetic makeup did not confer resistance to HIV infection. It would be interesting to know the CCR5 genotype of the mothers of the children in the study population. Since it remains unclear exactly how heterozygosity for CCR5Δ32 changes the natural course of the disease, one can imagine that the CCR5 genotype of mother or child or both could play an important role in the risk of transmission.