Margaret A.WinkerMD, Senior EditorIndividualAuthorPhil B.FontanarosaMD, Senior EditorIndividualAuthor
To the Editor.— The article by Dr Pincus and colleagues1 documents the near doubling in prescriptions for antidepressants since the introduction of SSRIs. These data raise concern as to the likelihood of a corresponding increase of significant adverse events attributable to these agents. All antidepressants, including the newer drugs, can produce behavioral toxic effects, namely, the induction of psychosis and mania.2 As an assessment of the prevalence and impact of antidepressant behavioral toxic effects, we examined the frequency of inpatient admissions required to manage psychosis precipitated by antidepressants.
Bowers MB, MacLean RW, Weiss E, Mazure CM. Trends in Prescribing Psychotropic Medications. JAMA. 1998;280(2):132–134. doi:10-1001/pubs.JAMA-ISSN-0098-7484-280-2-jac80010
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