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September 9, 1998

Sodium Reduction and Weight Loss for Elderly Patients With Hypertension—Reply

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Copyright 1998 American Medical Association. All Rights Reserved. Applicable FARS/DFARS Restrictions Apply to Government Use.1998

JAMA. 1998;280(10):885-886. doi:10-1001/pubs.JAMA-ISSN-0098-7484-280-10-jac80015

In Reply.—Our study design allowed for independent assessment of the effects of sodium reduction alone, weight loss alone, and the combination of sodium reduction and weight loss. The effects of these interventions on both the primary end point (diagnosis of hypertension, treatment with hypertensive medication, or a cardiovascular event) and on change in BP were described in the text and were displayed in Figures 4, 5, and 6 and Table 2. Change in BP identified the additional reduction in BP, which was achieved in hypertensive patients whose BP already was being well controlled with antihypertensive medication. Far from being modest, as Dr Alderman and colleagues suggest, the changes in BP were noteworthy, given the participants' baseline level of BP. In observational analysis, greater sodium reduction and greater weight loss were each associated with an increased likelihood of remaining free of any of the end points after controlling for intervention assignment (P<.05).1

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