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October 7, 1998

Alcohol Consumption and Breast Cancer Risk

Author Affiliations

Margaret A.WinkerMD, Senior EditorIndividualAuthorPhil B.FontanarosaMD, Senior EditorIndividualAuthor

JAMA. 1998;280(13):1138-1139. doi:10-1001/pubs.JAMA-ISSN-0098-7484-280-13-jbk1007

To the Editor: The combined analysis of 6 cohort studies by Dr Smith-Warner and colleagues1 provides evidence that alcohol consumption is associated with increased risk of breast cancer. Within a range between minimal and moderate consumption, the study demonstrates a dose-response relationship between alcohol intake and breast cancer risk. The intriguing finding is that women who consume a relatively large amount of alcohol do not show further increase in the risk of breast cancer. If this observation is true, it may indicate a potentially important biological mechanism underlying the association of alcohol with breast cancer risk.