Margaret A.WinkerMD, Senior EditorIndividualAuthorPhil B.FontanarosaMD, Senior EditorIndividualAuthor
In Reply.—Identifying characteristics beyond first-degree family history and early diagnosis age that might be associated with germline BRCA1mutation status would be of great assistance to the many women and clinicians who struggle with the decision of whether to proceed with genetic testing. Recent reports suggest that the spectrum of family history and age of onset features seen in BRCA1carriers is considerably less uniform and less predictive than expected from prior studies of high-risk families.1 These findings highlight the need to identify other common features of BRCA1mutation carriers. In describing their observations on BRCA1mutation frequency in relation to the occurrence of medullary tumors, Dr Eisinger and colleagues highlight the fact that histopathologic features of breast tumors may provide additional clues regarding BRCA1status.
Malone KE, Daling JR, Ostrander EA. BRCA1and Medullary Breast Cancer—Reply. JAMA. 1998;280(14):1227–1228. doi:10-1001/pubs.JAMA-ISSN-0098-7484-280-14-jbk1014