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November 11, 1998

Cardiac Complications and Delirium Associated With Valerian Root Withdrawal

Author Affiliations

Margaret A.WinkerMD, Senior EditorIndividualAuthorPhil B.FontanarosaMD, Senior EditorIndividualAuthor

JAMA. 1998;280(18):1566-1567. doi:10-1001/pubs.JAMA-ISSN-0098-7484-280-18-jbk1111

To the Editor.— Valerian (Valeriana officinalis) root is a widely used herbal product with putative sedative, hypnotic, and anxiolytic benefits1-4 similar to the benzodiazepines. Preparations recommend dosages ranging from 200 mg to several grams per day taken at bedtime or in divided doses. The optimal duration of use is not well established, although some preparations advise against long-term use. We report a case of serious cardiac complications and delirium associated with withdrawal of valerian root.