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December 2, 1998

Free PSA for Detecting Prostate Cancer

Author Affiliations

Margaret A.WinkerMD, Senior EditorIndividualAuthorPhil B.FontanarosaMD, Senior EditorIndividualAuthor

JAMA. 1998;280(21):1825. doi:10-1001/pubs.JAMA-ISSN-0098-7484-280-21-jbk1202

To the Editor.—The article by Dr Catalona and colleagues1 claims that the free PSA assay can reduce the number of biopsies performed in men with normal DRE findings and total PSA levels between 4.0 and 10.0 ng/mL, while missing only a minimal number of patients with prostate cancer. However, a critical examination of their data shows that the test has significant weaknesses and in fact is almost worthless.